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  1. Hannah Barnes, New Statesman, 6 December 2025:
    A new trial [in Britain] looking at the impact of puberty-suppressing hormones on children with gender incongruence (a mismatch between birth sex and gender identity) will begin in the new year, having received all the necessary regulatory and ethical approvals. The research, led by a team from King’s College London (KCL), aims to determine whether these drugs are of benefit to often vulnerable and distressed gender-questioning children, or if they could be harmful. Or, perhaps, both. But will the way the trial has been set up allow it to achieve that?
    ​​​ In March 2024, after a decade of routine clinical use, NHS​ ​England (NHSE) ended the prescription of puberty blockers for the treatment of gender-related distress, based on the findings of Dr Hilary Cass. Cass, a former president of the Royal College of Paediatrics and Child Health, led a four-year independent investigation into the care provided to gender-questioning young people on the NHS in England via the Gender Identity Development Service (Gids), part of the Tavistock and Portman NHS Foundation Trust. NHSE concluded that there was “​​not enough evidence to support the safety or clinical effectiveness of [puberty blockers] to make the treatment routinely available at this time​”.​ ​​
    In her final report, published in April 2024, Cass was clear: “This is an area of remarkably weak evidence, and yet results of studies are exaggerated or misrepresented by people on all sides of the debate to support their viewpoint.” The reality, she wrote, is that there is “no good evidence on the long-term outcomes of interventions to manage gender-related distress”. The outgoing Conservative government outlawed new puberty blocker prescriptions the following month, and the ban was made permanent in December 2024 by the current Labour regime. Puberty blockers – which Cass has described as “powerful drugs with unproven benefits and significant risks for children” – remain illegal in the UK outside of an NHS trial context.
    https://archive.ph/C4YbN

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